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International, Peer reviewed, Open access Journal ISSN Approved Journal No. 2582-8185

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ISSN Approved Journal || eISSN: 2582-8185 || CODEN: IJSRO2 || Impact Factor 8.2 || Google Scholar and CrossRef Indexed

Peer Reviewed and Referred Journal || Free Certificate of Publication

Research and review articles are invited for publication in March 2026 (Volume 18, Issue 3) Submit manuscript

Assessing the incidence of acute kidney injury with combination vancomycin and piperacillin-tazobactam therapy compared to that of vancomycin and cefepime

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  • Assessing the incidence of acute kidney injury with combination vancomycin and piperacillin-tazobactam therapy compared to that of vancomycin and cefepime

Sydney Jean Rechtenbaugh 1, Fekadu Fullas 1, *, Kimberly Ann Zellmer 1, Joseph Michael Buren 2, Corey James Thieman 1, and Michael Theodore Padomek 1

1 UnityPoint Health-St. Luke’s, Pharmacy Department, 2720 Stone Park, Boulevard, Sioux City, IA 51104, USA.
2 Sanford USD Medical Center, Pharmacy Department,1305 W18th St., Sioux Falls, SD 57117-5039; USA.

Research Article
 
International Journal of Science and Research Archive, 2021, 02(01), 143-148.
Article DOI: 10.30574/ijsra.2021.2.1.0040
DOI url: https://doi.org/10.30574/ijsra.2021.2.1.0040

Received on 03 February 2021; revised on 09 March 2021; accepted on 11 March 2021

Previous studies have shown a correlation between acute kidney injury (AKI) and combination antimicrobial therapy comprising piperacillin-tazobactam and vancomycin. In this study, AKIs were compared in patients who received vancomycin plus piperacillin-tazobactam with those who received vancomycin plus cefepime. We found a statistically significant increase in AKI risk in the vancomycin plus piperacillin-tazobactam group when compared to the vancomycin plus cefepime group using both AKI criteria [KDIGO 18.9% vs. 4.5% (p = 0.0012); RIFLE 11.2% vs. 1.8% (p = 0.0029)]. Vancomycin in combination with piperacillin-tazobactam led to an increased risk of AKI in comparison to vancomycin and cefepime.

Vancomycin Plus Piperacillin-Tazobactam; Vancomycin Plus Cefepime; AKI; KDIGO; RIFLE; Nephrotoxicity; Antibiotics, Antimicrobials

https://ijsra.net/sites/default/files/fulltext_pdf/IJSRA-2021-0040.pdf

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Sydney Jean Rechtenbaugh, Fekadu Fullas, Kimberly Ann Zellmer, Joseph Michael Buren, Corey James Thieman, and Michael Theodore Padomek. Assessing the incidence of acute kidney injury with combination vancomycin and piperacillin-tazobactam therapy compared to that of vancomycin and cefepime. International Journal of Science and Research Archive, 2021, 02(01), 143-148. Article DOI: https://doi.org/10.30574/ijsra.2021.2.1.0040

Copyright © Author(s). All rights reserved. This article is published under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits use, sharing, adaptation, distribution, and reproduction in any medium or format, as long as appropriate credit is given to the original author(s) and source, a link to the license is provided, and any changes made are indicated.

All statements, opinions, and data contained in this publication are solely those of the individual author(s) and contributor(s). The journal, editors, reviewers, and publisher disclaim any responsibility or liability for the content, including accuracy, completeness, or any consequences arising from its use.

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