Review on development and evaluation of ibuprofen gel by using natural polymer

Vaibhav Shankar Lokhande *, Mangesh Atmaram Khote, Nikhil Nandusing Chavhan, Prathamesh Sunil Gore, Ganesh Gopichand Gore, Kishor Rodge and R. H. Kale

PRMSS, Anuradha College of Pharmacy Chikhli, Maharashtra, India.
 
Review
International Journal of Science and Research Archive, 2024, 13(02), 3161-3166.
Article DOI: 10.30574/ijsra.2024.13.2.2540
Publication history: 
Received on 12 November 2024; revised on 18 December 2024; accepted on 21 December 2024
 
Abstract: 
The investigation focuses on developing and review of a topical gel that contains the painkiller Ibuprofen a nonsteroidal anti-inflammatory medication NSAIDS propylene glycol and Alovera gel or Guar gum were used as penetration enhancers to promote penetrate into the skin and as a gelling agent in the preparation of the gel to guarantee strength physical characteristics such as ph viscosity and appearance were assessed experiments on the releasing of substances within the body using flow-through diffusion cell demonstrated a prolonged release profile and experiments on skin permeation demonstrated efficient absorption tests for stability verified that the gel kept its characteristics under many circumstances the findings imply that this transdermal gel formulation presents a viable substitute for Ibuprofen delivery improving patient compliance by means of non-invasive administration more in vivo research is advised to confirm the therapeutic efficacy and safety of this intervention the investigation focuses on developing and review of a topical gel that contains the painkiller Ibuprofen a nonsteroidal anti-inflammatory medication nsaid propylene glycol and Alovera gel or Guar gum were used as penetration enhancers to promote penetration into the skin and as a gelling agent in the preparation of the gel to guarantee strength physical characteristics such as ph viscosity and appearance were assessed experiments on the releasing of substances within the body using flow-through diffusion cell demonstrated a prolonged release profile and experiments on skin permeation demonstrated efficient absorption tests for stability verified that the gel keptits characteristics under many circumstances the findings imply that this transdermal gel formulation presents a viable substitute for Ibuprofen delivery improving patient compliance by means of non-invasive administration more in vivo research is advised to confirm the therapeutic efficacy and safety of this intervention.
 
Keywords: 
Ibuprofen; Formulation of Gel; Topical Analgesic Application; Mechanism of gel formation; Factor affecting actual drug distribution
 
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