1 Faculty of Medicine, Centro Universitário Alfredo Nasser (UNIFAN), Aparecida de Goiânia-GO, Brazil.
2 Faculty of Medicine, Universidade Federal de Goiás (UFG), Goiânia-GO, Brazil.
3 Faculty of Medicine, Centro Universitário Alfredo Nasser (UNIFAN), Aparecida de Goiânia-GO, Brazil.
4 Faculty of Medicine, Universidade Evangélica de Goiás (UniEVANGÉLICA), Anápolis-GO, Brazil.
5 Faculty of Medicine, Centro Universitário Alfredo Nasser (UNIFAN), Aparecida de Goiânia-GO, Brazil; Department of Neurosurgery, Hospital das Clínicas, Universidade Federal de Goiás (HC-UFG/Ebserh), Goiânia-GO, Brazil.
6 Department of Neurology, Hospital das Clínicas, Universidade Federal de Goiás (HC-UFG/Ebserh), Goiânia-GO, Brazil.
* Corresponding Author
ORCID Details
Samella Soares Oliveira Medeiros: https://orcid.org/0009-0005-0371-3094
Pedro Henrique Lessa de Oliveira: https://orcid.org/0009-0000-4804-4617
João Victor Ferreira Guimarães: https://orcid.org/0009-0008-6177-0099
Vinicius Cavalcante Silva: https://orcid.org/0009-0007-8937-6766
Wander Nasser Naves: https://orcid.org/0009-0003-2254-4236
Lucas Wilson Matos Gomes: https://orcid.org/0009-0005-8506-0073
International Journal of Science and Research Archive, 2026, 21(01), 623–630
Article DOI: 10.30574/ijsra.2026.21.1.1941
Received on 15 September 2026; revised on 22 October 2026; accepted on 24 October 2026
This integrative review examined how inequalities in access to reperfusion for ischemic stroke, through intravenous thrombolysis and mechanical thrombectomy, relate to clinical outcomes. Sixteen publications from PubMed and SciELO, published in the last five years, were included. Findings were grouped into three themes and integrated through narrative synthesis. Studies described differences in reperfusion use by race and ethnicity, socioeconomic status, rural or urban residence, treating hospital and health system. In the Brazilian studies, thrombolysis predominated over thrombectomy and the regional distribution of services was uneven. In some investigations, social position was also associated with functional outcome after treatment. Most studies were observational and conducted in the United States, which limits causal inference and the transfer of findings to Brazil. The results point to the need to strengthen stroke care networks and to monitor access by group and territory.
Ischemic stroke; Thrombolytic therapy; Thrombectomy; Healthcare disparities; Health services accessibility.
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Samella Soares Oliveira Medeiros, Pedro Henrique Lessa de Oliveira, João Victor Ferreira Guimarães, Vinicius Cavalcante Silva, Wander Nasser Naves and Lucas Wilson Matos Gomes. INEQUALITIES IN ACCESS TO REPERFUSION IN ISCHEMIC STROKE AND THEIR IMPACT ON CLINICAL OUTCOMES: AN INTEGRATIVE REVIEW. International Journal of Science and Research Archive, 2026, 21(01), 623–630. Article DOI: https://doi.org/10.30574/ijsra.2026.21.1.1941.
