Dental stem cells and their application in dental research: A review

Promising advancements in dental therapies aimed at replacing, repairing, and regenerating dental tissues have resulted from recent innovations in cell and molecular-based dentistry. Additionally, fresh approaches to the study of human tooth organogenesis have also been established. In recent days, five subpopulations of dental and oral stem cells have been identified, including dental pulp SCs (DPSCs), SCs from human exfoliated deciduous teeth (SHEDs), periodontal ligament SCs (PDLSCs), dental follicle progenitor SCs (DFPCs), and SCs from apical papilla (SCAPs). Teeth are one of the most accessible and least invasive sources of stem cells. Despite being unique, these populations exhibit traits common to MSCs, such as the capacity for self-renewal and the capacity to split into at least three separate lineages. Here in this article, the different sources of Dental stems cells and their characteristic features are discussed.