The role of HLA-B27 in cancer immunity: Investigating its potential impact on tumour surveillance and response to immunotherapy

Niharika Harish *

Year 13 Student, St. Christopher School, Kingdom of Bahrain.
 
Review
International Journal of Science and Research Archive, 2024, 13(01), 725–733.
Article DOI: 10.30574/ijsra.2024.13.1.1678
Publication history: 
Received on 31 July 2024; revised on 08 September 2024; accepted on 10 September 2024
 
Abstract: 
This research paper specifically aims at identifying HLA-B27’s involvement in the anti-cancer immune response and response to immunotherapy especially in tumor detection. Hydroxylation of HLA-B27 may affect the immune system and chronic inflammation, which is responsible for cancer predisposition due to the molecule. The literature on the relationship between HLA-B27 and cancer forms and types is analyzed with the focus on the immunological and genetic mechanisms in the contexts of brain cancer. It points out the directions for the literature by outlining significant areas for further research to explain these mechanisms. The results have the following practical importance regarding the screening and individual approach this field is interested in improving the prevention and treatment of cancer for patients with HLA-B27 positive.
 
Keywords: 
Cancer Immunity; Autoimmune Disorders; Immunotherapy; Chronic Inflammation
 
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