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Comparing the efficacy of saffron with fluoxetine for the effective management of premenstrual dysphoric disorder: A review
Department of Pharmacy Practice, Arulmigu Kalasalingam College of Pharmacy, Krishnankoil, Virudhunagar-626126, Tamil Nadu, India.
Review
International Journal of Science and Research Archive, 2024, 12(02), 2001–2006.
Article DOI: 10.30574/ijsra.2024.12.2.1484
Publication history:
Received on 04 July 2024; revised on 13 August 2024; accepted on 15 August 2024
Abstract:
Premenstrual syndrome (PMS) significantly impacts the emotional and physical well-being of women of reproductive age. Various theories have been proposed about its etiology but still, it is unknown. The PMS starts from the luteal stage of women’s menstrual cycle and affects 20% to 40% of women in their reproductive phase. The severe form of PMS is PMDD which typically affects 3% - 5% of women in their reproductive phase. Standard treatments for these conditions include selective serotonin reuptake inhibitors such as fluoxetine, paroxetine, and sertraline. Fluoxetine is mainly used for the treatment of Premenstrual syndrome and Premenstrual dysphoric disorder. Fluoxetine appears to be more effective and better tolerated for treating physical and psychological symptoms associated with severe Premenstrual syndrome and Premenstrual dysphoric disorder. Herbal remedies like saffron (crocus sativus) consist of three bioactive compounds: procrocin, safranal, and crocin. Saffron exhibits SSRIs-like actions and is also used in the management of PMS and PMDD. This review critically evaluates the comparative effectiveness of saffron and fluoxetine in the management of PMDD, aiming to provide valuable insights for treatment decisions.
Keywords:
Saffron; Fluoxetine; PMDD; SSRIs; PMS
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