Serum fertility profile in infertile women in Calabar

Daniel Archibong Orok *, Ogbe Oyama Ikpan; Emem Efeffiom Eyo, Edima E. Duke and Deborah Andounimye Akepu

Department of Medical Laboratory Science, College of Health Technology, Mary Slessor Avenue, Calabar, Cross River State, Nigeria.
 
Research Article
International Journal of Science and Research Archive, 2024, 12(01), 3079–3087.
Article DOI: 10.30574/ijsra.2024.12.1.0968
 
Publication history: 
Received on 22 April 2024; revised on 25 June 2024; accepted on 28 June 2024
 
Abstract: 
This study was aimed to determine follicle stimulating hormone (FSH), luteinizing hormone (LH), Prolactin (PRL), progesterone (PROG), and estradiol (E2) levels in infertile women in Calabar. A total of ninety (90) subjects which comprises of thirty (30) menorrheic infertile women, thirty (30) amenorrheic infertile women and thirty (30) controls were enrolled into the study. The infertile women were further grouped into twenty three (23) primary and thirty seven (37) secondary infertile women. Blood samples were collected from menorrheic infertile women and control on third and twenty first day of the menstrual cycle. FSH, LH, estradiol, and prolactin were analysed using day three serum samples, while progesterone was analyzed using day twenty first samples using ELISA method. Random blood samples were collected from amenorrrheic infertile women and were assayed for FSH, LH, E2, prolactin, progesterone using ELISA method. Anthropometric indices and sociodemographic information were obtained using standard methods. Data were analyzed using student t-test, one-way analysis of variance (ANOVA). Significant difference was considered at p <0.05. The mean levels of FSH, LH, and prolactin were significantly higher (p = 0.001) while progesterone was significantly lower (p=0.001) in infertile women when compared to control. The WHR was significantly higher (p=0.037) in the secondary infertile women compared to the primary infertile women. Lower level of progesterone and higher levels of FSH, LH and prolactin may be associated with female infertility in Calabar. It is recommended that early estimation of these hormonal parameters and their management would possibly lead to increased chances of conception.
 
Keywords: 
Infertility; Follicle stimulating hormone; Luteinizing hormone; Estradiol; Progesterone; Prolactin
 
Full text article in PDF: 
 
Copyright information: 

Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0