Beyond the hype: A critical review of crispr-Cas9 gene editing therapies

Farheen Taj Shaik; Sravani Yarra

doi:10.30574/ijsra.2025.14.2.0492

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Beyond the hype: A critical review of crispr-Cas9 gene editing therapies

Farheen Taj Shaik ¹ and Sravani Yarra ^{2, *}

¹ Department of Pharmaceutics, Raghavendra Institute of Pharmaceutical Education and Research, K.R. Palli Cross, Anantapur, Chiyyedu, Andhra Pradesh-515721-India.

² Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research, K.R. Palli Cross, Anantapur, Chiyyedu, Andhra Pradesh-515721-India.

Review Article

International Journal of Science and Research Archive, 2025, 14(02), 1525-1539

Article DOI: 10.30574/ijsra.2025.14.2.0492

DOI url: https://doi.org/10.30574/ijsra.2025.14.2.0492

Publication history

Received on 08 January 2025; revised on 18 February 2025; accepted on 21 February 2025

Abstract

CRISPR-Cas9 gene editing has emerged as a revolutionary tool with the potential to reshape medicine. However, critical evaluation is necessary to navigate beyond the hype and assess its true therapeutic potential. This review examines the background, promise, and challenges of CRISPR-Cas9 therapies. It explores its simplicity, efficiency, and transformative impact on biological research. While acknowledging the excitement, the review emphasizes the need to address ethical concerns, off-target effects, delivery issues, and long-term safety. By critically appraising the efficacy, safety, and ethical considerations, this review aims to inform stakeholders about the realities of implementing CRISPR-Cas9 in clinical practice. Furthermore, it explores future directions in research and emphasizes the importance of responsible development and implementation to maximize benefits while minimizing risks.

Keywords

CRISPR-Cas9; Gene Editing; Therapeutic Potential; Ethical Concerns; Off-Target Effects

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How to cite this article

Farheen Taj Shaik and Sravani Yarra. Beyond the hype: A critical review of crispr-Cas9 gene editing therapies. International Journal of Science and Research Archive, 2025, 14(02), 1525-1539. Article DOI: https://doi.org/10.30574/ijsra.2025.14.2.0492.

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