Determination of the effect of co-administration of Andrographis paniculata leaves and Zingiber officinale rhizoids on serum liver enzymes in normal Albino wistar rats

The effect of administration of ethanol extracts of Andrographis paniculata leaves and Zingiber officinale rhizoids on serum liver enzymes (ASP, ALP and ALT) in normal male albino wistar rats, weighing 113-233g was evaluated. Twenty-five (25) animals were randomly assigned five groups of five rats each. Groups 1, 2, 3 and 4 were treated with 100mg/kg, 200mg/kg, 300mg/kg and 400mg/kg respectively of Andrographis paniculata leaves and Zingiber officinale rhizoids extracts. Group 5 (control) was not treated. Both treated and control animals were fed with commercial rat mash and water throughout three (3) weeks of experiments. At the end of the 21 days, significant decrease (P> 0.05) in serum AST level was recorded in treated groups 1, 2, 3 and 4 compared with the control. Significant decrease (P> 0.05) in serum ALP level was recorded in group 4 when compared with control. However, serum ALP level recorded significant increase in group 4 compared with group 3 (P>0.05). The results of this research work signified that administration of ethanol extracts of Andrographis paniculata leaves and Zingiber officinale rhizoids possessed no marked effects on the liver enzymes since variations in the levels of the enzymes were within their normal serum ranges.