Development and evaluation of anti-hemorrhoid alum suppositories

Sanskruti Vilas Pawshe and Bhavana Dnyandeo Tambe *

SMBT College of Pharmacy, Dhamangaon, Igatputi, Nashik, Maharashtra- 422403 India.
 
Research Article
International Journal of Science and Research Archive, 2024, 12(01), 131-141.
Article DOI: 10.30574/ijsra.2024.12.1.0760
Publication history: 
Received on 20 March 2024; revised on 27 April 2024; accepted on 30 April 2024
 
Abstract: 
Rectal suppositories of Alum were prepared using different bases and polymers like Shea butter, and PEG-4000 and its effect on the In-vitro release of Alum was studied. The Agar-based suppositories were non-disintegrating, and non-dissolving, whereas PEG-4000 based were disintegrating and dissolving. The Fusion Method and Trituration Method were used for the formulation of the suppositories. In-vitro tests were carried out on the formulations. All the formulated suppositories were tested for several physical parameters namely weight variation, drug content of suppositories, disintegration test, and dissolution rate. The PEG-4000 and Shea butter suppositories were of macro melting range, disintegration, and liquefaction time.
 
Keywords: 
Alum; PEG-4000; Shea butter; Suppositories; Anti-hemorrhoid
 
Full text article in PDF: 
 
Copyright information: 

Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0