Oxytocin: A key regulator of mitochondrial metabolism and energy homeostasis

Yuki Ueda *

UNI H and H Graduate School, Japan.
 
Review
International Journal of Science and Research Archive, 2024, 12(01), 063-071.
Article DOI: 10.30574/ijsra.2024.12.1.0734
Publication history: 
Received on 16 March 2024; revised on 27 April 2024; accepted on 29 April 2024
 
Abstract: 
Oxytocin, traditionally recognized for its roles in social bonding and reproductive behaviors, is emerging as a crucial regulator of mitochondrial metabolism and energy homeostasis. This review synthesizes current research illustrating how oxytocin influences cellular energy processes, particularly within the context of metabolic disorders. By interacting with oxytocin receptors in key metabolic organs, oxytocin modulates mitochondrial biogenesis, enhances glucose uptake, and optimizes energy utilization, thereby contributing to overall metabolic stability. Recent studies in rodent models highlight the potential of oxytocin analogs in ameliorating symptoms of metabolic syndromes, such as obesity and diabetes, by improving mitochondrial function and energy expenditure. This review aims to consolidate these findings, propose mechanisms of action, and discuss the therapeutic prospects of oxytocin in managing metabolic diseases. The implications of oxytocin’s metabolic effects extend beyond traditional reproductive and social domains, suggesting a multifaceted hormone with significant potential for addressing public health challenges related to metabolic disorders.
 
Keywords: 
Metabolic Syndrome; Mitochondrial Biogenesis; Glucose Homeostasis; Lipid Metabolism; Meditation; Music Therapy
 
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