Histological Change on mice Spleen treated with Aflatoxin B1

Safa Salah Salman; Raghad Abdullah Hassan; Mohanad Hasan Hussein

doi:10.30574/ijsra.2023.9.2.0660

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Histological Change on mice Spleen treated with Aflatoxin B1

Safa Salah Salman ¹, *, Raghad Abdullah Hassan ²and Mohanad Hasan Hussein ³

1 Biology Department, College of Science, Tikrit University, Iraq.
2 Biology Department, College of Education, Iraqia University, Iraq.
3 Molecular and medical biotechnology Department, College of Biotechnology, Al-Nahrain University, Iraq.

Research Article

International Journal of Science and Research Archive, 2023, 09(02), 844–848.

Article DOI: 10.30574/ijsra.2023.9.2.0660

DOI url: https://doi.org/10.30574/ijsra.2023.9.2.0660

Publication history

Received on 04 July 2023; revised on 19 August 2023; accepted on 21 August 2023

Abstract

The results appeared that in this study, histopathological examination of spleen of mouse treated with 12, 25, 50 μgmL-1 of Aflatoxin B1. gross-examination showed clear pathological changes in examined spleen of showed deposition of amyloid like substance in congested red pulp in other section ,the main lesions characterized by inflammatory cells particularly mononuclear cells infiltration in congested red pulp fatty changes were seen in spleen in addition to extensive apoptosis of lymphocytes in white pulp that characterized by cellular debris in multiple irregular spaces the spleen revealed mononuclear cells in congested blood vessels with depletion of white pulp with apoptosis of lymphocytes in white pulp.

Keywords

Aspergillus flavus; Aflatoxin B1; Spleen; Necrosis; Mice.

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How to cite this article

Safa Salah Salman, Raghad Abdullah Hassan and Mohanad Hasan Hussein. Histological Change on mice Spleen treated with Aflatoxin B1. International Journal of Science and Research Archive, 2023, 09(02), 844–848. Article DOI: https://doi.org/10.30574/ijsra.2023.9.2.0660

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