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Polygenic Hazard Score and Amyloid PET Imaging Mediation Analysis in Alzheimer’s Disease Diagnosis
1 Institute of Biological Sciences, University of Rajshahi, Rajshahi, Bangladesh.
2 Department of Computer Science and Engineering, Daffodil International University, Dhaka, Bangladesh.
3 Bangladesh University of Professionals, Mirpur Cantonment, Dhaka-1216, Bangladesh.
4 Dhaka National Medical College, Dhaka, Bangladesh.
Research Article
International Journal of Science and Research Archive, 2023, 10(02), 1451-1457.
Article DOI: 10.30574/ijsra.2023.10.2.0980
Publication history:
Received on 18 October 2023; revised on 21 November 2023; accepted on 29 November 2023
Abstract:
This work studies the mediating role of amyloid PET imaging quantitative traits (QTs) in the relationship between genetic risk, measured by the Polygenic Hazard Score (PHS), and Alzheimer’s disease (AD) diagnosis. Data are obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI), including 559 participants classified as Normal (NL), early mild cognitive impairment (EMCI), late mild cognitive impairment (LMCI), or AD. Thirteen amyloid QTs from AV45 PET scans are examined as potential mediators between PHS and diagnostic outcomes using mediation analysis, Chow tests, and mixed-effects models. Results indicate partial mediation for all QTs in multiple diagnostic comparisons, with both direct and indirect effects being statistically significant. These findings suggest that amyloid PET measures explain part, but not all, of the link between genetic predisposition and AD diagnosis.
Keywords:
Polygenic Hazard Score; Alzheimer’s Disease; Amyloid PET Imaging; Mediation Analysis; Quantitative Traits; Genetic Risk; AV45 PET; Neuroimaging Biomarkers
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Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
