Therapeutic indication of caffeine and vitamin c on haematological profile in heparin, phenylhydrazine and aspirin induced haematological derangements in male Wistar rats

Oghogho Okporu 1, *, John C. Igweh 1 and Oyovwi O. Mega 2

1 Department of Human Physiology, Delta State University, Abraka, Delta State, Nigeria.
2 Department of Physiology, Adeleke University, Ede, Osun State, Nigeria.
 
Research Article
International Journal of Science and Research Archive, 2023, 10(01), 242–251.
Article DOI: 10.30574/ijsra.2023.10.1.0617
Publication history: 
Received on 21 June 2023; revised on 08 September 2023; accepted on 11 September 2023
 
Abstract: 
Background: Caffeine and Vitamin C, key component in foods and beverages, have been investigated for potential haematological disease prevention.
Aim: To lend credence to the above studies, the current study in Wistar rats evaluated the effects of caffeine and vitamin C in the management of haematological disorders in rats.
Methods: Experimental animals were divided into three experimental phases (anaemic, leukocytopenic, and thrombocytopenic phases). Interventions with caffeine and vitamin C during anaemic, leukocytopenic, and thrombocytopenic phases were initiated for two weeks. Haematological parameters were all tested. All test, statistics were run using the Graph Pad Prism 8.1 at a confidence level of 0.05 or less (p-value).
Results: After analysis, caffeine and vitamin C shows a significant increase in RBC, PCV, Hb count in the anaemic treated rats when compared to control. Similarly, there was a significant increase in platelet count in the thrombocytopenic treated rats when compared to untreated thrombocytopenic group. There was also a significant increase in monocyte, lymphocyte and neutrophil counts in leukocytopenic animals compared to luukocytopenic group untreated.
Conclusion: In conclusion, this study suggests that caffeine and vitamin C have haemoprotective effects against anaemic, leukocytopenic and thrombocytopenic conditions.
 
Keywords: 
Anaemic; Leukocytopenic; Thrombocytopenic; Haemological indices; Caffeine
 
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