Regenerative medicine for diabetes: Unraveling the impact of stem cells

Snnehaa Bhosale 1, *, Vishal Girbane 2, Meera Deshmukh 1 and Pranati Tilak 2

1 TMV’s Lokmanya Tilak Institute of Pharmaceutical Science’s Pune. Mukund Nagar, Maharashtra, India.
2 Department of Pharmacy, TMV’s Lokmanya Tilak Institute of Pharmaceutical Science’s Pune, Mukund Nagar, Maharashtra, India.
 
Review
International Journal of Science and Research Archive, 2024, 11(01), 1917–1932.
Article DOI: 10.30574/ijsra.2024.11.1.0263
Publication history: 
Received on 04 January 2024; revised on 13 February 2024; accepted on 14 February 2024
 
Abstract: 
Diabetes poses a significant health challenge, particularly in developing nations, with an alarming annual increase in cases. Current medications mainly focus on managing hyperglycemia and preventing complications associated with diabetes. However, the article underscores the potential of stem cells in advancing diabetes treatment, particularly in the generation of insulin-producing β-cells. It highlights the damage to these cells within the islet of Langerhans in diabetic patients, whether through autoimmune reactions in type 1 diabetes or inherent changes affecting β-cell function in type 2 diabetes. The article suggests that cell replacement strategies, such as islet transplantation, could offer therapeutic options for diabetes. Stem cells, capable of differentiating into specialized cells, are presented as a promising avenue for creating insulin-producing β-cells, aiming to restore normal insulin levels and providing a more comprehensive and long-term solution compared to current medications. While the potential is promising, it's essential to note that stem cell therapies are still in the experimental stage, necessitating further research and clinical trials to establish their safety and efficacy for widespread use in diabetes treatment.
 
Keywords: 
Diabetes; insulin-producing; β-cells. stem cell; Cell replacement
 
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