"A prospective study of etiology and outcome of acute febrile illness with multi-organ dysfunction syndrome " in patients admitted in intensive care unit

IRFAN MANIYAR; ASHOK P. YENKANCHI; MARIYA SULTANA U. PANFAROSH

doi:10.30574/ijsra.2025.16.1.2191

ISSN Approved Journal || eISSN: 2582-8185 || CODEN: IJSRO2 || Impact Factor 8.2 || Google Scholar and CrossRef Indexed

Peer Reviewed and Referred Journal || Free Certificate of Publication

Research and review articles are invited for publication in March 2026 (Volume 18, Issue 3) Submit manuscript

"A prospective study of etiology and outcome of acute febrile illness with multi-organ dysfunction syndrome " in patients admitted in intensive care unit

IRFAN MANIYAR ^{1, *}, ASHOK P. YENKANCHI ¹and MARIYA SULTANA U. PANFAROSH ²

¹ Department of General Medicine, Al-Ameen Medical College and Hospital, Vijayapura, Karnataka, India.

² Department of Obstetrics and Gynaecology, KMCRI, Hubballi, Karnataka, India.

Research Article

International Journal of Science and Research Archive, 2025, 16(01), 1584-1594

Article DOI: 10.30574/ijsra.2025.16.1.2191

DOI url: https://doi.org/10.30574/ijsra.2025.16.1.2191

Publication history

Received on 14 June 2025; revised on 18 July 2025; accepted on 22 July 2025

Article DOI:

Abstract

Background: Acute Febrile Illness (AFI) is a frequent cause of ICU admissions in tropical regions like India. Although often self-limiting, AFI can progress to Multi-Organ Dysfunction Syndrome (MODS), resulting in significant morbidity and mortality.

Objective: To identify the etiology, clinical predictors, and outcomes of AFI progressing to MODS.

Methods: A prospective observational study was conducted over 18 months in a medical ICU. Patients with AFI and MODS (≥2 organ dysfunctions) were evaluated for demographic, clinical, laboratory, and microbiological parameters. Disease severity was assessed using SOFA score.

Results: Dengue, malaria, leptospirosis, rickettsial infections, and bacterial sepsis were common causes. Mortality correlated with elevated creatinine, bilirubin, CNS involvement, low MAP, and thrombocytopenia. Mixed infections increased mortality risk.

Conclusion: MODS due to AFI poses a critical care challenge. Early identification of high-risk patients using simple markers can guide timely management and improve outcomes, particularly in resource-limited settings.

Keywords

AFI (Acute Febrile Illness); MODS (Multi-Organ Dysfunction Syndrome); Tropical Infections; Critical Care; SOFA Score; Mortality Predictors

Download Article PDF

https://journalijsra.com/sites/default/files/fulltext_pdf/IJSRA-2025-2191.pdf

Preview Article PDF

How to cite this article

IRFAN MANIYAR, ASHOK P. YENKANCHI and MARIYA SULTANA U. PANFAROSH. "A prospective study of etiology and outcome of acute febrile illness with multi-organ dysfunction syndrome " in patients admitted in intensive care unit. International Journal of Science and Research Archive, 2025, 16(01), 1584-1594. Article DOI: https://doi.org/10.30574/ijsra.2025.16.1.2191.

Copyright © Author(s). All rights reserved. This article is published under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits use, sharing, adaptation, distribution, and reproduction in any medium or format, as long as appropriate credit is given to the original author(s) and source, a link to the license is provided, and any changes made are indicated.

All statements, opinions, and data contained in this publication are solely those of the individual author(s) and contributor(s). The journal, editors, reviewers, and publisher disclaim any responsibility or liability for the content, including accuracy, completeness, or any consequences arising from its use.