POEMS syndrome masquearading as Tuberculosis

Sonika Mayanglambam 1, *, LH Ghotekar 2, Madhur Yadav 2, Shivraj Meena 3, Shubham Goswami 4 and Bangkim Kshetrimayum 5

1 Senior Resident, Department of Medicine, Lady Hardinge Medical College, New Delhi, India- 110001.
2 Director Professor, Department of Medicine, Lady Hardinge Medical College, New Delhi, India -110001.
3 Associate Professor, Department of Medicine, Lady Hardinge Medical College, New Delhi, India -110001.
4 Senior Resident, Department of Clinical hematology and Oncology, Rajiv Gandhi Cancer Institute and Research, Rohini, New Delhi, India-110085.
5 Assistant Professor, Department of Architecture, School of Planning and Architecture, New Delhi, India-110002.
 
Review
International Journal of Science and Research Archive, 2023, 08(01), 954–959.
Article DOI: 10.30574/ijsra.2023.8.1.0179
Publication history: 
Received on 07 January 2023; revised on 18 February 2023; accepted on 20 February 2023
 
Abstract: 
POEMS syndrome, also called Osteosclerotic myeloma or Takatsuki syndrome or Crow-Fukase syndrome, is a rare multisystemic disease paraneoplastic syndrome under the plasma cell dyscrasias. POEMS is an acronym for Polyneuropathy, organomegaly, endocrinopathy, monoclonal protein elevation, and skin changes. It is usually 1.5 times more common in male than female. Patients often present in the fifth to sixth decades of life and have a median survival rate of 8 to 14 years without successful treatment. 
Here we described a case of POEMS syndrome in a young 30 years old adult who presented with anasarca, polyneuropathy as initial manifestation and masquerading as tuberculosis. He was successfully treated with Melphalan-Dexamethasone therapy with clinical improvement.
Therefore, patients with unexplained polyneuropathy especially when it is associated with endocrinopathy, skin changes or oedema, should be evaluated for POEMS syndrome.
 
Keywords: 
POEMS syndrome; Anasarca; Polyneuropathy; Tuberculosis
 
Full text article in PDF: 
 
Copyright information: 

Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0