Overview on pulsatile drug delivery system

Kundan Rajendra Mahajan, Ashish Prakash Gorle * and Vijay Sanjay Khalane

Department of Pharmaceutical Technology, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, (425405), Maharashtra, India.
 
Research Article
International Journal of Science and Research Archive, 2022, 05(02), 110–118.
Article DOI: 10.30574/ijsra.2022.5.2.0067
Publication history: 
Received on 19 February 2022; revised on 27 March 2022; accepted on 29 March 2022
 
Abstract: 
Traditionally, drugs are released in an immediate or extended fashion. However, in recent years, pulsatile drug release systems are gaining growing interest. Pulsatile drug delivery systems are developed to deliver drug according to circadian behavior of diseases. The product follow a sigmoidal drug release profile characterized by a time period of no release (lag time) followed by a rapid and complete drug release. Pulsatile systems are gaining a lot of interest as they deliver the drug at the right site of action at the right time and in the right amount, thus providing spatial and temporal delivery and increasing patient compliance. Pulsatile release systems can be classified in multiple-pulse and single-pulse systems. A popular class of single-pulse systems is that of rupturable dosage forms. Other systems consist of a drug-containing core, covered by a swelling layer and an outer insoluble, but semipermeable polymer coating or membrane. The potential benefits of chronotherapeutics have been investigated and established for number of diseases like asthma, arthritis, cancer, diabetes, epilepsy, hypertension, ulcer, hypercholesterolemia etc.
 
Keywords: 
Pulsatile Delivery; Osmosis; Membrane Erosion; Solubilization
 
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