Methemoglobinemia caused by nitrobenzene ingestion treated with methylene blue and ascorbic acid: A case report

G. Ramya Balaprabha *, Vaishali Akshitha and T. Rama Rao

CMR College of pharmacy, medchal, hyderabad, Telangana, India.
 
Research Article
International Journal of Science and Research Archive, 2024, 11(02), 1885–1887.
Article DOI: 10.30574/ijsra.2024.11.2.1005

 

Publication history: 
Received on 23 October 2023; revised on 01 December 2023; accepted on 04 December 2023
 
Abstract: 
Nitrobenzene (NBZ) is a pale-yellow coloured compound, moderately water-soluble oily liquid, and odour similar to bitter almonds. It is commonly used in the manufacture of aniline, benzidine, quinolone, drugs, dyes, solvent in shoe, metal polishes, and in screen printing]. It is a potent oxidizer of the iron moiety of haemoglobin causing methemoglobinemia leading to its inability to transport oxygen. Clinical features of nitrobenzene poisoning include gastric irritation, nausea, vomiting, cyanosis, drowsiness, seizures, coma and finally respiratory failure culminating in death. Intravenous methylene blue and ascorbic acid are commonly used for treatment of significant poisoning.
 
Keywords: 
Nitrobenzene; Methemoglobinemia; Methylene blue; Ascorbic acid
 
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