Mebeverine hydrochloride in pharmaceutical preparation as determined by spectrophotometer using the Ion Association Reaction

Nahlah Jaber Hussein; Hussein Ali Al-Bahrani; Ali A. Sabi

doi:10.30574/ijsra.2025.14.1.0066

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Mebeverine hydrochloride in pharmaceutical preparation as determined by spectrophotometer using the Ion Association Reaction

Nahlah Jaber Hussein ^{1, *}, Hussein Ali Al-Bahrani ² and Ali A. Sabi ²

¹ Department of Chemistry, College of Education for Pure Science, University of Kerbala, Iraq.

² Department oof Pharmaceutical Chemistry, Faculty of Pharmacy, University of Kufa, Iraq.

Research Article

International Journal of Science and Research Archive, 2025, 14(01), 146-152

Article DOI: 10.30574/ijsra.2025.14.1.0066

DOI url: https://doi.org/10.30574/ijsra.2025.14.1.0066

Publication history

Received on 30 November 2024; revised on 04 January 2025; accepted on 07 January 2025

Abstract

A simple, accurate, and sensitive colorimetric method for determining Mebeverine HCL. Pure and pharmaceutical preparations have been developed. The method is based on the formation of an ion-association combination between picric acid and the medication. The range was measured with the maximum absorption at 382.00 nm. With a molar absorptivity of 3.41×10⁴ Mol L^-1cm^-1, a relative standard deviation (RSD %) of 0.6430 percent, a mean recovery of 90.776-98.055%, and a correlation value of Between 1.0 and 30.0 µg/ml, the beer's law is observed (r² = 0.990). This method successfully identified mebeverine HCL in pharmaceutical formulations and bulk.

Keywords

Spectrophotometric Determination; Mebeverine HCL; Picric Acid

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How to cite this article

Nahlah Jaber Hussein, Hussein Ali Al-Bahrani and Ali A. Sabi. Mebeverine hydrochloride in pharmaceutical preparation as determined by spectrophotometer using the Ion Association Reaction. International Journal of Science and Research Archive, 2025, 14(01), 146-152. Article DOI: https://doi.org/10.30574/ijsra.2025.14.1.0066.

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