A longitudinal observational study on activated partial thromboplastin time in hypothyroidism and effect of thyroxine supplementation

JAYACHANDRA B *, ANAND NANASAHEB PATIL and AMEEQ AHAMED

Department of General Medicine, Al-Ameen Medical College and Hospital, Vijayapura, Karnataka, India.
: 
Research Article
International Journal of Science and Research Archive, 2024, 13(01), 2768–2776.
Article DOI: 10.30574/ijsra.2024.13.1.1974
Publication history: 
Received on 03 September 2024; revised on 15 October 2024; accepted on 17 October 2024
 
Abstract: 
Background: Hypothyroidism is a common condition characterized by thyroid hormone deficiency, which, if untreated, can lead to severe health consequences and even death. Due to the wide range of clinical presentations and non-specific symptoms, hypothyroidism is primarily diagnosed biochemically. It can result from congenital thyroid abnormalities or iodine deficiency.
Aims and objectives: Aim: To evaluate the correlation between hypothyroidism and Activated Partial Thromboplastin Time (aPTT) and assess the effect of thyroxine supplementation.
Objective: To study the impact of levothyroxine supplementation on aPTT in hypothyroid patients.
Materials and methods: This observational study was conducted at the General Medicine outpatient clinic and inpatient wards at Al-Ameen Medical College and Hospital, Vijayapura, from September 2022 to March 2024. A total of 80 hypothyroid patients of both sexes were included. TSH, Free T4, and aPTT levels were measured with appropriate aseptic precautions.
Results: The majority of subjects were females (90%), with the highest proportion (31.3%) aged 26-35 years. The mean ± SD of pre-thyroxine TSH was 25.453 ± 19.9073, which significantly decreased to 4.299 ± 0.6738 post-thyroxine. aPTT values also decreased significantly post-treatment. A positive correlation was found between TSH and aPTT, while aPTT had a negative correlation with T3 and T4 levels.
Conclusion: aPTT is significantly elevated in hypothyroid patients and shows a positive correlation with TSH levels. Regular monitoring of aPTT should be included in the follow-up of hypothyroid patients.
 
Keywords: 
Hypothyroidism; aPTT; TSH; Levothyoxine supplementation; Pre-thyroxine and Post thyroxine-aPTT
 
Full text article in PDF: 
 
Copyright information: 

Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0