Lead Compounds for Brain Protection against Alzheimer’s

Alwah R Al-Ghamdi, Iman S Issa and Huda S Al-Salem *

Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.
 
Research Article
International Journal of Science and Research Archive, 2023, 10(01), 1029–1057.
Article DOI: 10.30574/ijsra.2023.10.1.0214
Publication history: 
Received on 01 February 2023; revised on 02 April 2023; accepted on 05 April 2023
 
Abstract: 
To find a promising drug for treatment of Alzheimer’s` is not that easy target. Although some medications have FDA approval for management of AD, all of them offer symptomatic benefits. This is because efforts to find the treatment are distributed among many targets in the brain which make it so difficult to find a drug that can correct all of them at once. The primary histopathologic lesions of Alzheimer’s pathology are amyloid plaques, NFTs and neuronal loss with a wide genetic background which deteriorate the patient condition so rapidly. In the current article, we highlight some lead compounds that protect brain cells from undergoing this dark pathway or, which is more important, to stop deterioration and worsening of the case after starting of the disease. sex lead compounds of natural sources suggested as anti-AD drugs with brief discussion of each of them regarding its chemistry, physiochemical properties, mechanism of action, bioavailability, derivatives and method of synthesis. These natural extracts can be expected as lead compounds for design and synthesis of more effective derivatives as prophylactic treatment against Alzheimer’s. The aim of our review is to help to direct efforts to treat AD toward the prophylactic choice according to research results and scientific facts.
 
Keywords: 
Alzheimer’s`; Epigallocatechin-3-gallate; Dementia; Curcumin; Lead compounds; Quercetin; Beta amyloid
 
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Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0