Invasive lobular triple negative carcinoma of breast: A clinico-pathological study done in south eastern part of India

Ubaidullah Sayeed Mohammed 1, * and Durga kharidehal 2

1 Department of Pathology, College of Medicine, Jouf University, Sakaka, Al Jouf, Kingdom of Saudi Arabia.
2 Department of Pathology, Osmania Medical College, Hyderabad, India.
 
Research Article
International Journal of Science and Research Archive, 2023, 08(01), 727–733.
Article DOI: 10.30574/ijsra.2023.8.1.0134
Publication history: 
Received on 28 December 2022; revised on 06 February 2023; accepted on 08 February 2023
 
Abstract: 
Background: Triple Negative Breast Carcinomas (TNBC) are breast carcinomas which are negative for Estrogen receptor (ER) Progesterone receptor (PR) and no overexpression of Human Epidermal Growth Factor receptor-2 (HER-2). The five-year survival rate for breast carcinomas in general is good but the same is bad for TNBC. TNBC has got worse prognosis compared to hormone positive breast carcinomas.
Aim: The aim of present study is to compare invasive lobular TNBC with invasive ductal TNBC with morphologic, immunohistochemical and prognostic parameters.
Materials and Methods: One-year study was done at Tertiary Care Centre. Patients of all ages were included. Most of them were in 4th and 5th decade. Mammography, FNAC and Biopsy was done. Formalin-fixed mastectomy specimens received at MGM hospital are screened, diagnosed histopathologically for carcinoma of breast over a period of one year. Immunohistochemistry (IHC) was performed to diagnose TNBC.
Results: Total no of cases – 72. No of Cases with positive ER, PR and or Her 2/neu are – 61. No of Cases with ER, PR and Her 2/neu negative (Triple negative) – 11 Percentage of Triple negative cases – 15 %. Most of the TNBCs show high grade and high mitotic count 74% and 82% respectively. Other hand, some cases 60% showed only ER and PR positivity without Her-2 and 25% showed only Her-2 positivity without ER and PR. Invasive lobular TNBC subtype is reported in 18%.
Conclusion: Overall TNBCs are high grade aggressive tumors and are more common in younger age groups. Whereas TNBCs associated with invasive lobular carcinoma are more common in 5th decade and were more aggressive compared to other subtypes.
 
Keywords: 
Invasive lobular carcinoma; Triple Negative Breast Carcinoma (TNBC); ER; PR; Her 2/ neu
 
Full text article in PDF: 
 
Copyright information: 

Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0