Histological Change on mice Spleen treated with Aflatoxin B1

Safa Salah Salman 1, Raghad Abdullah Hassan 2 and Mohanad Hasan Hussein 3

1 Biology Department, College of Science, Tikrit University, Iraq.
2 Biology Department, College of Education, Iraqia University, Iraq.
3 Molecular and medical biotechnology Department, College of Biotechnology, Al-Nahrain University, Iraq.
 
Research Article
International Journal of Science and Research Archive, 2023, 09(02), 844–848.
Article DOI: 10.30574/ijsra.2023.9.2.0660
Publication history: 
Received on 04 July 2023; revised on 19 August 2023; accepted on 21 August 2023
 
Abstract: 
The results appeared that in this study, histopathological examination of spleen of mouse treated with 12, 25, 50 μgmL-1 of Aflatoxin B1. gross-examination showed clear pathological changes in examined spleen of showed deposition of amyloid like substance  in congested red pulp in other section ,the main lesions  characterized  by  inflammatory cells particularly  mononuclear cells infiltration in congested red pulp  fatty changes were  seen in spleen in addition to  extensive apoptosis of lymphocytes in white  pulp that characterized  by cellular debris in  multiple irregular spaces  the spleen revealed  mononuclear cells in congested blood vessels  with depletion of white pulp with apoptosis of lymphocytes in white pulp. 
 
Keywords: 
Aspergillus flavus; Aflatoxin B1; Spleen; Necrosis; Mice.
 
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