Evaluation of the antiproliferative activity of three types of Annona muricata extract in the traditional treatment of cervical cancer induced in Wistar rats

Agossou Esse, Akotegnon Rodrigue, Savoeda Perside, Behanzin G. Justin and Sezan Alphonse *

Laboratory of Pharmacology and Improved Traditional Medicines, Department of Animal Physiology, Faculty of Science and Technology, University of Abomey-Calavi, BP 526 Cotonou, Republic of Benin.
 
Research Article
International Journal of Science and Research Archive, 2023, 09(01), 308–317.
Article DOI: 10.30574/ijsra.2023.9.1.0170
Publication history: 
Received on 26 February 2023; revised on 28 May 2023; accepted on 30 May 2023
 
Abstract: 
This study was concerned with the evaluation of the antiproliferative activity of Annona muricata in the traditional treatment of cervical cancer induced in Wistar rats. The aim of the present work was to compare the effect of ethyl, dichloromethane and ethyl acetate extracts of Annona muricata leaves to determine the most effective one on cervical cell differentiation in wistar rats.
For this purpose, we made three extracts namely: ethyl extract, dichloromethane and ethyl acetate) from dried leaf powder of Annona muricata. The antiproliferative (anticancer) activity was evaluated by assaying the alkaline phosphatase and total protein parameters on cervical crushings of Wistar rats, in which cervical cancer was previously induced by exposure to Cycas revoluta extract through gavage of 100mg/kg of the ethyl extract of Cycas revoluta.
The antiproliferative (anticancer) activity was effective by administration of a dose of 100 mg/kg of ethyl, dichloromethane and ethyl acetate extracts of Annona muricata leaves. This activity showed a variation of intensity according to the type of extracts. Thus the dichloromethane extract was the most active.
 
Keywords: 
Annona muricata; Cycas Revoluta; Cervical Cancer; Antiproliferative; Extracts; Differentiation.
 
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