Effects of topical doxycycline on serum prooxidant marker levels in periodontal disease: A pilot study

Ricardo Andreu 1, Mayte Martinez-Herrera 1, 2, *, José-Manuel Cruz-Valiño 3, 4, Laura Delgado-Lobete 4, Francisco Payri-Gonzalez 5 and Sergio Santos-del-Riego 4

1 Andreu Dental Clinic, C/ Major 45, 46980 Paterna, Valencia, Spain.
2 Department of Stomatology, University of Valencia, C/ Gasco i Oliag 1, 46010 Valencia, Spain.
3 Sonrident Dental Clinic, C/ Vicente Aleixandre 59, 15011, A Coruña, Spain.
4 Department of Physiotherapy, Medicine and Biomedical Sciences, Investigation Unit in Integration and Health Promotion (INTEGRA SAÚDE), Faculty of Health Sciencies, University of A Coruña, 15071 A Coruña, Spain.
5 Polytechnic University of Valencia, Camí de Vera, 46022 Valencia, Spain.
 
Research Article
International Journal of Science and Research Archive, 2023, 09(01), 222-230.
Article DOI: 10.30574/ijsra.2023.9.1.0396
Publication history: 
Received on 10 April 2023; revised on 19 May 2023; accepted on 22 May 2023
 
Abstract: 
The aim of this study is to determine the changes in the serum levels of malondialdehyde and 8-hydroxy-2'-deoxyguanosine, as indicators of oxidative stress, in response to periodontal treatment adyuvanted with topical doxycycline.
Methods: Thirty four patients with periodontal disease were studied (DOX group n=16; Control group n=18), determining the serum levels of malondialdehyde and 8-hydroxy-2'-deoxyguanosine in urine at baseline and three months after non-surgical periodontal treatment.
Results: We observed a slight trend to decrease in 8-OHdG urine levels after periodontal treatment, being this decrease greater in the DOX group (t1: 9.64 ± 7.18 μg/g; t0: 9.84 ± 3.01 μg/g) than in the control group (t1: 8.79 ± 4.08 μg/g; t0: 8.82 ± 4.01 μg/g). However, these changes were not statistically significant. No changes in serum levels of MDA were observed after periodontal treatment. BOP was positively correlated with 8-OHdG, in the DOX group (r = 0.563, p = 0.018).
Conclusion: Periodontitis, as a local inflammatory disease, can cause an increase in oxidative stress, thus opening the way to new therapeutic strategies, while exploring novel strategies for modulating the host response.
 
Keywords: 
Periodontal diseases; 8-hydroxy-2′-deoxyguanosine; Malondialdehyde; Oxidative stress; Topical doxycycline
 
Full text article in PDF: 
 
Copyright information: 

Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0