Comparison of the efficacy of Dexmedetomidine, Clonidine and control in attenuating Intubation response

Siddartha Patta * and Ram Manohar Reddy P

Department of Anesthesiology, NRI Medical College, Guntur, A.P, India.
 
Research Article
International Journal of Science and Research Archive, 2023, 08(02), 142–153.
Article DOI: 10.30574/ijsra.2023.8.2.0208
Publication history: 
Received on 28 January 2023; revised on 10 March 2023; accepted on 12 March 2023
 
Abstract: 
Endotracheal intubation includes laryngoscopy & intubation. The process of laryngoscopy & intubation are noxious stimuli & therefore constitute a period of extreme hemodynamic stress and is associated with intense sympathetic activity marked by tachycardia & hypertension 1. Hence the search for an ideal agent to attenuate the hemodynamic responses is still continuing. Alpha-2 agonists have been used for attenuating the sympathetic response21 and among α-2 agonists both Clonidine and Dexmedetomidine appear to fulfil all the criteria of ideal agent.
The study was undertaken to compare the effects of Dexmedetomidine and Clonidine in attenuating hemodynamic response to laryngoscopy and intubation. This study was done in 90 patients divided into 3 groups, in operation theatre in the department of anesthesiology, NRIAS.
This study showed that IV bolus dose of Dexmedetomidine 1 mcg/kg administered 10 minutes before laryngoscopy and intubation can be recommended to attenuate the sympathetic response to laryngoscopy and intubation without any side effects than clonidine.
 
Keywords: 
Dexmedetomidine; Clonidine; Intubation response; Attenuation; Laryngoscopy
 
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