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Biosafety assessment and In vitro antioxidant activity of Musanga cecropioides root sap
1 Department of Biological Sciences, Faculty of Science, Edo State University Uzairue, Edo State, Nigeria.
2 Department of Mathematics, Faculty of Science, Edo State University Uzairue, Edo State, Nigeria.
Research Article
International Journal of Science and Research Archive, 2024, 12(02), 1326–1345.
Article DOI: 10.30574/ijsra.2024.12.2.1364
Publication history:
Received on 16 June 2024; revised on 26 July 2024; accepted on 28 July 2024
Abstract:
The present study evaluated the biosafety and in vitro antioxidant activity of Musanga cecropioides root sap, a traditional remedy known for its health benefits. The sap was found to be rich in bioactive compounds, including alkaloids, tannins, saponins, flavonoids, and phenols, confirming existing literature. Proximate analysis revealed high moisture, fat, and protein content, alongside significant levels of essential vitamins and amino acids, indicating potential nutritional and therapeutic benefits. Acute toxicity assessments in mice demonstrated safety at doses up to 100 ml/kg, while the sub-acute toxicity assessment using rats showed no significant changes in haematological parameters or liver and kidney function markers. Histological examinations showed minor, non-significant alterations in liver and lung tissues. Antioxidant assays (DPPH and ABTS) revealed considerable radical scavenging activities, attributed to the presence of known antioxidant compounds. These findings support the traditional use of Musanga cecropioides root sap, highlighting its potential as a natural therapeutic agent. Further research is recommended to explore its mechanisms and clinical efficacy, paving the way for its development into a standardized natural remedy.
Keywords:
Musanga cecropioides; Bioactive compounds; Antioxidant activity; Toxicity assessment; Traditional medicine; phytochemicals
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Copyright © 2024 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
