Assessing the antiumer and anti-inflammatory potentials of Calotropis procera latex

Ruqaya Mohammed Al-ezzy 1, *, Asmaa Sabah Ahmaed 2, Nidhal Mohammed Saleh 2 and Shaymaa Hameed Al-Obaidy 2

1 College of Biotechnology, Al-Nahrain University, Baghdad, Iraq.
2 College of Agricultural Engineering Sciences\University of Baghdad\Baghdad\Iraq.
 
Research Article
International Journal of Science and Research Archive, 2021, 04(01), 086–091.
Article DOI: 10.30574/ijsra.2021.4.1.0183
Publication history: 
Received on 16 October 2021; revised on 25 November 2021; accepted on 27 November 2021
 
Abstract: 
Since time immemorial medicinal plants have been used in healthcare to treat different human disease. The ideals of medicinal plants are highlighted due to the utility of the common-factor approach to engage other health promoters in propagating. One of these medicinal plants is Calotropis procera which is a species of tree in the family Apocynaceae. Calotropis procera is widespread in tropical Africa, including the Indian Ocean islands and the northern parts of South Africa. The latex is toxic and can cause rash, blisters and serious inflammations in sensitive persons and it may lead to blindness. Several side effects may be caused due to ingestion large doses of latex like burning in the throat, irritation of the stomach, nausea, vomiting, diarrhea, tremors, vertigo and convulsions. This study aimed to evaluate burns healing effects and inhibitory concentration IC50 of Calotropis procera latex on cervical cancer cell line, SiHa. Cytotoxicity analysis was performed by MTT assay in addition to determine the burns healing effect of the latex by determining the day requiring to heal the burn skin of albino male mice. The results of burns healing effects declared that the burns required 12 days to heal in comparison with positive (sliver sulfadiazine) and negative control which required 16 and 18 days for healing respectively. Also, the results revealed that the IC50 of latex was 146.8 % in comparison of ambiguous percentage of normal cell line WRL68 with reduction in cancer cell viability ranging from 95.87± 0.20to 52.35 ±3.31 for 6.2 to 400 µg\ml respectively.
 
Keywords: 
Calotropis procera; Latex; SiHA cell line; Burns healing; Anticancer
 
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