Acute oral toxicity study of Acideem Plus Tablet: An Ayurvedic polyherbal formulation

Objective: This study aimed to evaluate the acute oral toxicity of Acideem Plus Tablet in female wistar rats.
Materials and Methods: 12 rats were divided into four groups of three at random. Group 1 acted as the control and merely received distilled water. Acideem Plus Tablet, doses of 2000 mg/kg body weight, was given to groups 2 and 3, while group 4 received doses of 5000 mg/kg body weight. For 14 days, the rats were monitored for any indications of toxicity. At the end of the study period, all rats underwent necropsy, and gross pathology was documented.
Results: According to the results, neither the rats in the treatment group nor the control group displayed any clinical indications of toxicity or mortality over the course of the 14-day observation period. The LD50 value was found to be greater than 5000 mg/kg body weight.
Conclusions: The acute oral toxicity study of Acideem Plus Tablet in wistar rats concluded no adverse effect at doses up to 5000 mg/kg body weight. These results demonstrated the safety of the Acideem Plus Tablet's oral administration.