Achard-Thiers syndrome in post-menopausal women: The hidden complexity

Shivani Sureshchandra Thaker 1, Srija Reddy Kesireddy 2, *, Kavya Ammineni 3, Gul-E-Zernab 4, Rida Asghar 5, Srijamya 6 and Munawar Izhar 7

1 Department of Medicine, Odessa national medical university, Ukraine.
2 Department of Medicine, S.V.S Medical college, Telangana, India.
3 Department of Medicine, PES institute of medical sciences and research, Kuppam, Andhra Pradesh, India.
4 Department of Medicine, Benazir Bhutto Shaheed Medical college, Mirpur, AJK, Pakistan.
5 Department of Medicine, Lahore medical and dental college, Pakistan.
6 Department of Medicine, Ivane Javakhishvili Tbilisi State University, Tbilisi, Georgia.
7 Department of Medicine, The University of Chicago Hospitals and Health System, Chicago, IL, USA.
 
Research Article
International Journal of Science and Research Archive, 2024, 13(01), 170–176.
Article DOI: 10.30574/ijsra.2024.13.1.1661
Publication history: 
Received on 28 July 2024; revised on 03 September 2024; accepted on 06 September 2024
 
Abstract: 
ATS, a rare disorder primarily affecting postmenopausal women, is characterized by the coexistence of DM Type 2 and elevated androgen levels. Despite its rarity, the syndrome poses diagnostic challenges due to its masked presentation under the guise of DM Type 2 and cosmetologic uses.
This study presents two unique cases of ATS, each with distinct onset scenarios, one following pregnancy and the other post-surgical transfusion. Both cases exhibit common symptoms of hirsutism and clitoromegaly, further emphasizing the importance of prompt and accurate diagnosis.
Laboratory, imaging, and clinical assessments play pivotal roles in identifying ATS amidst overlapping symptoms. Treatment options include hormone replacement therapy, antiandrogen therapy, glucose management, and cosmetic procedures. These cases show how important it is to have high clinical suspicion and a full evaluation to make sure that ATS is quickly identified and effectively treated in postmenopausal women who also have DM Type 2. 
 
Keywords: 
Achard-Thiers syndrome; Insulin resistance; Type 2 Diabetes mellitus; Hyperandrogenism; Post menopausal women
 
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