Évaluation of the anti-malarial properties of the combined aqueous and alcoholic extract of Heliotropium indicum and Parquentina nigrescencs

Faloye DA 1, *, Muoneke JN 2, Onyemeh LO 3, Ofor OC 4, Patricia ON 5, Temitope S 6 and Ekeke TE 7

¹ Department of Pharmacology, OBAFEMI AWOLOWO University, Nigeria.
² Department of Medicine and Surgery, Enugu State University of Science and Technology, Nigeria.
³ Department of Pharmacology and Therapeutics, Delta State University, Nigeria.
⁴ Department of Biochemistry, Ebonyi State University, Nigeria.
5 Department of Biology Education, Niger Delta University, Nigeria.
6 Department of Biochemistry, Redeemer's University, Nigeria.
7 Department of Microbiology, Abia State University, Nigeria.
 
Research Article
International Journal of Science and Research Archive, 2023, 10(01), 802–811.
Article DOI: 10.30574/ijsra.2023.10.1.0825
Publication history: 
Received on 02 September 2023; revised on 10 October 2023; accepted on 13 October 2023
 
Abstract: 
This research investigates the potential antimalarial efficacy of combined extracts derived from Heliotropium indicum and Parquetina nigrescens, considering their traditional applications in addressing various ailments, including malaria.
The primary objective is to assess the suppressive antimalarial activity of the combined extracts and compare it with individual extracts, utilizing toxicity assessments and syrup formulations.
The study includes LD50 assessments to confirm the safety of the extracts, employing doses beyond 5000mg/kg. Suppressive assays are conducted on mice, evaluating both individual and combined extracts, with varying doses.
White mice from a reputable source are used for the experiments. The extracts are prepared as syrups, and different doses are administered to the mice for toxicity and antimalarial assessment. Parasitemia is evaluated through blood films, and statistical analysis is performed.
The obtained data are analyzed using one-way ANOVA and Student-Newman Keul’s test to determine statistical significance. Results are expressed as mean ± SEM.
LD50 assessments reveal the safety of the extracts, and suppressive assays demonstrate significant antimalarial effects for both individual extracts at distinct doses. The combined aqueous extract shows promising outcomes, indicating potential synergistic interactions.
Traditional plant-based remedies, such as Heliotropium indicum and Parquetina nigrescens, hold promise for developing innovative antimalarial strategies. The combined extract exhibits potential as a complementary antimalarial intervention, warranting further exploration and research in the field of malaria management.
 
Keywords: 
LD50; Suppressive assay ; Syrups; Antimalarial; ANOVA.
 
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Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0