Association between diabetes and depression: A narrative review

Background: A major global health concern, diabetes mellitus affects 422 million people worldwide, with a higher prevalence in low- and middle-income nations. At almost 74 million diagnosed cases, India comes in second. Incidences as grave as neuropathy and cardiovascular disease are associated with the increasing frequency. Comorbid depression is a serious but largely disregarded problem that affects up to 38% of people in India who have type 2 diabetes and has a substantial negative influence on quality of life. Social and clinical factors such as age, gender, and glycemic control influence the association between diabetes and depression. Inflammatory reactions and lifestyle decisions also play a role in this link. For better health results, this co-occurrence must be addressed. Tailored therapies are needed as the burden of both illnesses increases, especially in developing nations.
Methods: A Comprehensive literature search was conducted, which were sourced google scholar, PubMed, WHO website, international diabetes federation.
Conclusion: Diabetes and depression have a significant and complex relationship that affects millions of people worldwide, but particularly in places like India. Diabetes and depression frequently coexist, and the course of each condition is adversely affected by the other. Since each disorder appears to function in longitudinal research as both a risk factor and a consequence for the other, the direction of causality is unclear. diabetes is becoming a more widespread public health concern, improving the quality of life and general well-being of this group will depend on recognizing and treating the co-occurrence of depression. For data to inform best practices in healthcare delivery, future research should concentrate on creating tailored interventions and comprehending the complex dynamics of this crucial link.