Role of Cinnamomum verum leaves in the management of Vascular dementia: A comprehensive overview

Shivam Thakur *, Abhay Sharma, Karan Thakur, Ayush Balihar, Mohit Sharma, Sunil Kumar and Aman Thakur

Gautam College of Pharmacy, Hamirpur, Himachal Pradesh, India.
 
Review
International Journal of Science and Research Archive, 2024, 11(02), 678–699.
Article DOI: 10.30574/ijsra.2024.11.2.0490
Publication history: 
Received on 12 February 2024; revised on 19 March 2024; accepted on 22 March 2024
 
Abstract: 
Spices are utilized for both culinary and medicinal purposes and have been for a very long time originating from Sri Lanka and southern India, Cinnamomum verum may also be found in other Asian, Caribbean, Australian, and African countries. The principal compounds contained are Cinnamaldehyde and Eugenol, both of which have unique medicinal qualities in the leaves of Cinnamomum verum. Cinnamonaldehyde (CA), a bioactive phytochemical offer therapeutic advantages against the beginning of cardiovascular illnesses. Eugenol is an organic compound found in the leaves of Cinnamomum verum. Eugenol has antihypercholesterolemic and antiatherogenic effects. Eugenol's smooth muscle relaxant effect is due to its inhibition of receptor-operated and voltage-sensitive channels. Endothelial cells create nitric oxide (NO), which relaxes blood vessels. Eugenol has substantial anti-inflammatory properties. The antipyretic activity of eugenol is well recognized, since it reduces fever by reducing prostaglandin and sodium archidonate synthesis. Eugenol's hydrophobic nature allows it to pass the blood-brain barrier and enter the brain. Eugenol protects neuronal cells against the oxidative and excitotoxic effects of N-methyl-D-aspartate (NDMA). Eugenol has neuroprotective properties in hippocampal tissues due to its capacity to reduce brain-derived neurotrophic factor (BDNF) and postpone amyloid β -peptide (A- β) induced cell death via abnormal Ca2+ blocking. Anti-hypertensive property of Eugenol is known as it has the ability to activate TRPV channels and to relax endothelium-depleted arteries. Eugenol, which is found in Cinnamomum verum leaves, has been shown to be beneficial in the control of hypertension and so may be beneficial in the management of vascular dementia.
 
Keywords: 
Cinnamomum verum; Cinnamon; Eugenol; Anti-hypertensive; Neuroprotective; Vascular dementia
 
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