Prevalence of Folate Deficiency in Patients with Depressive Symptoms: Biochemical and Clinical Implications

Roberto Lozano; Carina Bona

doi:10.30574/ijsra.2025.16.3.2738

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Prevalence of Folate Deficiency in Patients with Depressive Symptoms: Biochemical and Clinical Implications

Roberto Lozano ^{1, *} and Carina Bona ²

¹Department of Pharmacy, University clinical hospital“Lozano Blesa”, Zaragoza, Spain.

²Unit for the Rational Use of Medicines, Aragon Health Service, Zaragoza, Spain.

Review Article

International Journal of Science and Research Archive, 2025, 16(03), 1334-1337

Article DOI: 10.30574/ijsra.2025.16.3.2738

DOI url: https://doi.org/10.30574/ijsra.2025.16.3.2738

Publication history

Received on 23 August 2025; revised on 28 September 2025; accepted on 30 September 2025

Abstract

Objective: To evaluate the prevalence of folate deficiency in patients presenting with depressive symptoms and to explore associated biochemical abnormalities and clinical implications.

Methods: Observational study analyzing serum folate, vitamin B12, ferritin, thyroid function, and homocysteine levels in patients with depressive symptoms.

Results: Folate deficiency was prevalent in a significant subset of patients and was frequently associated with vitamin B12 deficiency, iron deficiency, and thyroid dysfunction.

Conclusion: Folate deficiency is a common and potentially modifiable factor in depression, underscoring the need for routine biochemical screening in psychiatric care.

Keywords

Folate deficiency; Depression; Homocysteine; Ferritin; Vitamin B12; Thyroid function

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How to cite this article

Roberto Lozano and Carina Bona. Prevalence of Folate Deficiency in Patients with Depressive Symptoms: Biochemical and Clinical Implications. International Journal of Science and Research Archive, 2025, 16(03), 1334-1337. Article DOI: https://doi.org/10.30574/ijsra.2025.16.3.2738.

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