Formulation and characterization of Carbopol based caffeine hydrogel transdermal film

Akshay Kumar; Shivam Mishra; Badal Kumar; Pankaj Sharma; Ekta

doi:10.30574/ijsra.2025.15.1.1086

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Formulation and characterization of Carbopol based caffeine hydrogel transdermal film

Akshay Kumar, Shivam Mishra, Badal Kumar and Pankaj Sharma and Ekta^*

Department of Pharmaceutics, School of Health Sciences, Sushant University, Gurugram, Haryana, India, 122003,

Research Article

International Journal of Science and Research Archive, 2025, 15(01), 882-887

Article DOI: 10.30574/ijsra.2025.15.1.1086

DOI url: https://doi.org/10.30574/ijsra.2025.15.1.1086

Publication history

Received on 04 March 2025; revised on 14 April 2025; accepted on 16 April 2025

Abstract

A transdermal patch containing caffeine was developed using Carbopol-940 as the hydrogel matrix. Caffeine transdermal films were made utilizing the solvent casting method with the lipophilic PEG-1500 and hydrophilic carbopol-940. As a plasticizer, propylene glycol (PG) was employed. The drug content, thickness, tensile strength, folding durability, and in vitro drug release—which was investigated using Franz diffusion cells—were all assessed for these films.

The purpose of the study was to publish physicochemical data, including in vitro drug release, and the film-forming capabilities of the polymers utilized.

PEG-1500, carbopol-940, and PG as a plasticizer were found to have good film-forming qualities. According to the results, the formulation of caffeine made solely with Carbopol-940 and 20% PG was the most flexible and had the best folding endurance of the two polymers employed. Subsequent research on the drug release of PEG 1500 and caffeine has revealed 88.32% and 87.28% release via the rat skin, respectively.

Keywords

Caffeine; Hydrogel; Ethanol; PEG-1500; Carbopol-940; Transdermal Film; Topical Formulation

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How to cite this article

Akshay Kumar, Shivam Mishra, Badal Kumar, Pankaj Sharma and Ekta. Formulation and characterization of Carbopol based caffeine hydrogel transdermal film. International Journal of Science and Research Archive, 2025, 15(01), 882-887. Article DOI: https://doi.org/10.30574/ijsra.2025.15.1.1086.

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