Exploring the neutrophil-to-lymphocyte ratio as a prognostic biomarker in triple-negative breast cancer

Mittal Mistry; Heer Shah; Hemangini Vora

doi:10.30574/ijsra.2024.12.1.0688

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Exploring the neutrophil-to-lymphocyte ratio as a prognostic biomarker in triple-negative breast cancer

Mittal Mistry ¹, Heer Shah ²and Hemangini Vora ^{3, *}

1 Ph. D Student, Department of Life sciences, Gujarat University, JRA, The Gujarat Cancer & Research Institute, Ahmedabad, Gujarat, India
2 Ph. D Student, Department of Life sciences, Gujarat University, Ahmedabad, Gujarat, India.
3 Professor and Head, Cancer Biology Department, The Gujarat Cancer and Research Institute, Gujarat, India.

Research Article

International Journal of Science and Research Archive, 2024, 12(01), 275–285.

Article DOI: 10.30574/ijsra.2024.12.1.0688

DOI url: https://doi.org/10.30574/ijsra.2024.12.1.0688

Publication history

Received on 16 April 2024; revised on 02 May 2024; accepted on 04 May 2024

Abstract

Triple-negative breast cancer is a subtype characterized by the absence of estrogen receptor, progesterone Receptor, and Human Epidermal Growth Factor Receptor 2 receptors, limiting treatment options primarily to chemotherapy due to lack of targeted therapies typically used for other breast cancer types, hence necessitating research for improved therapeutic strategies and outcomes. The neutrophil and lymphocyte percentages, absolute counts, and the ratio of neutrophils to lymphocytes were evaluated in peripheral blood of 81 patients with triple-negative breast cancer (TNBC) and 25 healthy controls. This study observed trend of high neutrophil percentage was observed in patients with positive lymph node status as compared to negative lymph node status. Significant high absolute neutrophil count was observed in patients with positive LN status, High BR score and presence of metastasis. A trend of high neutrophil to lymphocyte ratio was observed in patients with presence of perineural invasion, presence of necrosis, and patients with presence of metastasis.

Keywords

TNBC; NLR; DFS; OS

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How to cite this article

Mittal Mistry, Heer Shah and Hemangini Vora. Exploring the neutrophil-to-lymphocyte ratio as a prognostic biomarker in triple-negative breast cancer. International Journal of Science and Research Archive, 2024, 12(01), 275–285. Article DOI: https://doi.org/10.30574/ijsra.2024.12.1.0688

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