1 Department of Psychiatry, Mohammed V Military Training Hospital, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco.
2 Department of Psychiatry, Oued Eddahab Training Hospital, Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech, Morocco.
International Journal of Science and Research Archive, 2025, 17(02), 701–703
Article DOI: 10.30574/ijsra.2025.17.2.3096
Received 08 October 2025; revised on 15 November 2025; accepted on 18 November 2025
Background: Cocaine is a potent psychostimulant known to precipitate acute psychiatric manifestations, including manic or psychotic episodes. Hematological complications are rare but increasingly described, particularly thrombocytopenia associated with toxic or immune-mediated mechanisms.
Case Presentation: We report the case of a 32-year-old man with no psychiatric history who developed an acute manic episode following massive cocaine use. Laboratory evaluations revealed severe thrombocytopenia (30,000/mm³) without hemorrhagic manifestations. Infectious, immunological, and hematological investigations were unremarkable. Cocaine-induced thrombocytopenia was diagnosed. Clinical improvement was observed under olanzapine, with full normalization of platelet count after cocaine withdrawal.
Conclusion: This case illustrates the need for rigorous diagnostic exclusion and interdisciplinary collaboration when managing psychiatric presentations associated with unexpected hematological abnormalities in cocaine users.
Cocaine; Thrombocytopenia; Manic Episode; Levamisole; Toxicology; Hematological Complications; Drug-Induced Cytopenia
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Mamouni Alaoui Youness, Akanour Adil, Mansouri Wafaa and Kadiri Mohamed. Cocaine-Induced Manic Episode and Severe Thrombocytopenia: A Complex Diagnosis of Exclusion in a Young Adult: A case Report. International Journal of Science and Research Archive, 2025, 17(02), 701–703. Article DOI: https://doi.org/10.30574/ijsra.2025.17.2.3096.
