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Aqueous extract of Sea buckthorn berries: A greener and ecofriendly medium for synthesis of pyrazolopyranopyrimidines
Department of Chemistry, Shivaji University, Kolhapur, Maharashtra, 416004, India.
Research Article
International Journal of Science and Research Archive, 2024, 11(02), 1986–2004.
Article DOI: 10.30574/ijsra.2024.11.2.0706
Publication history:
Received on 09 March 2024; revised on 23 April 2024; accepted on 26 April 2024
Abstract:
Sustainable development and environmental consciousness have become increasingly important, leading to a revolution of industrial processes and organic synthesis methods. The use of organic solvents and their associated emissions has emerged as a significant environmental issue. Consequently, there is a growing emphasis on finding substitutes for volatile solvents and halogenated organic solvents in various synthetic processes. This study focuses on a greener and more eco-friendly approach to synthesizing pyrazolopyrimidine derivatives using sea buckthorn aqueous extract as a sustainable medium. Sea buckthorn berries, rich in phenolic compounds, fatty acids, and vitamins A, C, E, along with high organic acid content, are conducive to multicomponent reactions. Pyrazolyl derivatives are of particular interest due to their role as essential components in various biologically active compounds. Overall, this methodology offers a green and environmentally sustainable alternative to current protocols, with positive implications for both sustainability and economic factors. Additionally, Sea buckthorn berry extract proves to be a recyclable medium, with minimal decrease in product yields upon recycling.
Keywords:
Sea Buckthorn; Biocatalyst; Ecofriendly; Multicomponent reaction; pyrazolopyranopyrimidines
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