Advances in gastroretentive drug delivery systems: Formulation strategy and therapeutic applications

Megha Hansan *, Serene E Mathew, Anna Maria Irene and Muhammed Nishal. K

Department of Pharmaceutics, Indira Gandhi Institute of Pharmaceutical Sciences, Perumbavoor, Ernakulam Dist, kerala, India.
 
Review
International Journal of Science and Research Archive, 2024, 11(01), 1078–1088.
Article DOI: 10.30574/ijsra.2024.11.1.0168
Publication history: 
Received on 21 December 2023; revised on 27 January 2024; accepted on 30 January 2024
 
Abstract: 
Gastroretentive drug delivery systems (GRDDS) have emerged as a promising approach to enhance the bioavailability and therapeutic efficacy of orally administered drugs, especially those with a narrow absorption window or those susceptible to rapid gastrointestinal transit. This systems which may retained in the stomach for a prolonged period of time and thereby improve the bioavailability of drugs and inturn achieve the desired outcome. This review provides a comprehensive overview of the various gastro retentive drug delivery systems, including their formulation strategies, mechanisms of retention, and applications in drug delivery. Their breakthrough into this drug delivering field had played a pivotal role in further developing the new strategies which we were facing problems in passing the clinical trials phases. Mainly we should focus on the Selection of the right technology for the right purpose through the right mechanism of action for attaining the end system with desired therapeutic outcomes. Several examples of recently available GRDDS systems as marketed formulation.
 
Keywords: 
Bioavailability; Therapeutic window; Gastric emptying; Residence time; Buoyancy; Bioadhesion; Expansion; High-density formulation
 
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